The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds
This important study (Sullivan et al) examines the relationship between disc calcification (measured by K-number/K-n) and the FGF4L2 gene in Dachshunds. Here are the key findings from the analysis of a sample of Norwegian and Finnish Dachshunds:
Genetics and Disc Health:
- Dachshunds with one normal copy of the gene (N/FGF4L2) have significantly better spinal health than those with two copies of FGF4L2
- 75% of dogs with one normal copy had the best possible score (K0)
- 98% of dogs with at least one normal copy had low-risk scores (K0-K2)
- Only 1% of dogs with one normal copy had high-risk scores (K5+)
Practical Implications:
- Breeding dogs with one normal copy (N/FGF4L2) is likely to produce puppies with better spinal health
- Both K-number and FGF4L2 status should be considered when choosing breeding stock
- Given the gene's high frequency in Dachshunds, aiming for one normal copy is more practical than trying to breed for two normal copies
Risk Levels:
- K0: ~7% risk of disc disease
- K1/2: ~12% risk
- K3/4: ~23% risk
- K5+: ~69% risk
The researchers recommend developing breeding strategies that prioritise dogs with at least one normal copy of the gene, while using K-number scores to help select among dogs with two copies of FGF4L2.
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